Having her family murdered by the humans during her people's banishment from the surface world, Krista and her only friend, Darkwing, struggle to remain alive. The pair of reptilian street scum live in their newfound home, the City of Renasence, dictated by a fascist military known as the Renasence Guard. The two find themselves at odds when Krista puts her faith in the Five Guardians' goal of unification, while Darkwing chooses to stand with a notorious gang, the Blood Hounds, who are known for their anarchist views.
This divide in their friendship forces Krista to persist on her own as the Five Guardians become crazed from an unknown disease—Mental Damnation. After their infection, the Guardians develop a bizarre interest in her, claiming they must reap her innocence for their newfound master, the Weaver.
With a military dictatorship, politically-driven gangs, and their guardians infected and on a hunt for her, Krista has limited options for survival: Does she fend for her life in the City of Renasence, against menacing forces, or risk leaving everything behind and enter the uncharted realm of the underworld?